According to the study, quinolone-resistant strains accounted for more than 85% of S Typhi (the bacteria that causes Typhoid fever) in Bangladesh by the early 2000s, increasing to more than 95% in India, Pakistan and Nepal by 2010.

Typhoid-causing bacteria have increasingly become resistant to critically important antibiotics like quinolone, and have spread widely over the past 30 years, according to the study published in the Lancet, which also said that quinolone-resistant strains in India increased to more than 95% in the 2000s.

According to the study, quinolone-resistant strains accounted for more than 85% of S Typhi (the bacteria that causes Typhoid fever) in Bangladesh by the early 2000s, increasing to more than 95% in India, Pakistan and Nepal by 2010.

The mutations causing resistance to azithromycin-a widely used macrolide antibiotic-also have emerged at least seven times in the past 20 years, it said.

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